I dl'ed that game and noticed in my WinUAE enviroment it is shown on the Workbench as DF0:NDOS ... mmm maybe wrong disk ? naaa...
however the meaning in both cases is just one: game has to be load when the Amiga boots, and can't be launched from WB.
This procedure is likely to be the same for very old game (those from A500) that were not AmigaDOS formatted, but used a different scheme of storing stuff on the disk (trackloaders if I'm correct).
These procedures also allows the game developers to store much more data on a single DD floppy than standard 837kb (OFS).
The disk seems to be also protected, and some protections on the Amiga make just some files to appear from Workbench, not all.
So if you wanna play this game is to insert the disk in drive DF0 and then reboot the Amiga.
You can use one of the Amiga Forever configuration for vanilla A500 to play the game...
Hope it helps !
/ipino