No hardware changes will be necessary if a new core (fpga and/or PIC firmware) is released. The only thing you will need is a serial (RS232) crossover cable to update the PIC firmware via TinyBootloader PC software.
Maybe Jakub will release a PIC replacement board in order to gain more function (dfx: & hdf support) and faster data connection. This board will be placed in the existing PIC socket near by the sd-card slot.
If you want Minimig for "working like" issue in workbench, it will be very compatible to an Amiga500/1000/2000 in its limits: 68000 @ 7/14MHz, 1.5MB of RAM and currently df0: only support.
Some few games and demos dont work 100%. Mostly there are graphics bugs left, some very few don't start or even less freez somewhere.
Im also looking forward to the next core release... I hope Jakub will show some results soon. Anyway it's an open source project and we all are waiting to see some improvements to base on in the future.