If Amiga want's to be on the edge. It better have memory protection. And something else that make it worthwhile to ditch an Intel core CPU at Gigahertz with Gigabytes of DRAM. And of course I/O interfaces to match like PCI-express.
I know the Intel architecture sucks rotten horse eggs (little endian, segments, cpuid, bus smartness). But instructions per second per dollar, it's hard to beat. And should one for example want to run an FPGA synthesiz. That software is x86 only asfaik.