The problem shows when you alter instruction sets, register structure, etc.. which will kill the capability to run exisiting software. Increasing memory, frequency, caches, etc..
If you want updated performance, try Intel Core (MIPS for freedom, or ARM for efficiency might be alternatives), Intel graphics (free API), it ends up being a PC. Though ARM + Graphics is becoming more common as well. However any compatability goes out the window. Also modern systems use memory protection, preemptive multitasking, virtual memory, and user accounts which asfair AmigaOS doesn't support.
It's too bad that Intel/Compaq bought up all good processor projects. NVidia have their super propietary stuff, etc..