The Tower expansion units do just that, add more ISA slots for either a BridgeBoard or Toaster.
The IBM expansion model would likely work, but why?
Yes, my Ambitious Technology 4000 tower has an Amiga 4000 desktop motherboard and a big board ( I think it was called "Big Bertha") full of ISA slots for TBC's etc.
BTW, having the motherboard mounted on it's side saved it from the dreaded NiCad. The battery had leaked, but the liquid dripped off the board on to the bare metal at the bottom of the case.