Hi,
Do a search on YouTube for "Amiga Deluxe Paint". There are several tutorial videos for using it for animation on there. These are videos that were sold commercially in the 1980s/90s.
http://www.youtube.com/watch?v=S04TCNGkSD4http://www.youtube.com/watch?v=gfc0Slzf-sYDeluxe Paint IV and V and Disney Animation Studio are the best because they have onion-skinning. I tried MoveSetter but didn't like it because of the lack of onion-skinning, which makes it really hard to base the next frame on the old one (you can't see the old one). I don't know how Eric Schwartz did so well with Movie Setter.
http://en.wikipedia.org/wiki/Onion_skinning