In an Amiga 4000 for example.
Lets hypothetically say, the Mainboard has 16MB of ram, with a Cyberstorm 060, WITHOUT any ram.
That is going to CHOKE beyond belief while the 060 waits for the system bus to access the ram on the mainboard. Then we add the ram to the 060, fully populate the Cyberstorm board with 128MB of ram, at which point it no longer needs to wait, the 060 with ram SCREAMS with speed, it only needs to access the main system to access the Custom chips, and/or IDE. (That is also why Cyberstorms have their own SCSI).