OS4 is PowerPC based; thus, a PowerPC solution is best practical option. A mobileGT MGT5200 from freescale would need a 6 layer PCB for the BGA at which point a Spartan3e in BGA form might as well be used. DDR soldered onto the PCB is possible if you have enough experience with DDR and SI simulation tool available. The BGAs would require a reflow oven of some sort to fabricate the PCB. A simplier/easier step would be to use off the shelf the EFIKA MGT5200 board and build a PCI MiniMIG card for use with EFIKA with a Spartan3e, some DDR/SDRAM, a VGA output, PS2 connectors (mouse/keyboard), Joystick ports, serial port, IDE, etc ...
:-)