It would need a redesign. Here's a pic showing both sides of the FPGA board. There's no easy access to the PS-2 lines that I can see:
http://technabob.com/blog/wp-content/uploads/2011/03/fpga_arcade_board_detail.jpg
Darrin,
The board has a small patch array at the top for extra IO. This can be used to drive the LEDs and probably the USB. I have a small microprocessor inside the FPGA running the PS2 interfaces, and I am working on modifying this speak USB. Then, either an external passive adapter on the PS2 connector, or the pinheader, could be used to connect a USB mouse/ keyboard.
A quicker solution is an i2c or spi to USB bridge which I can bolt on.
Cheers,
Mike