Take a look on Aros.
It's not binary compatible yet but if you already want to do some programming, then you can recompile a lot of stuff for Aros.
Especially MUI programs are pretty easy to do, as Aros has its own MUI replacement (ZUNE).
There is not much software for Aros at this moment, but things are growing steady.
If you want to setup a Aros machine, ask at aros-exec which Hardware is best compatible:
http://aros-exec.org/Also take a look at the Aros Archives for Software:
http://archives.aros-exec.org/If you really need binary compatibility, you can use E-UAE on Aros.