I'll start of by saying that I have no illusions that the Amiga will be taking over the world. That being said, each year, there is a better chance of Amiga making a come back. Sure phones are hip right now, but as far as desktops go, I would say that a desktop actually DOESN'T need thousands of apps to be successful. The number of apps needed is dropping dramatically. Fewer people are gaming on PCs, or at least a smaller percentage of the whole. More and more apps are moving to the web. I would say that if a new OS really only needs a full browser, a decent media player, VPN and VNC to be usable by the vast majority of the population.
It isn't because Amiga will be superior that it could make a comeback. It is because there are people fanatic enough about it that the necessary pieces are likely to be built, and pretty much any system that has the few necessary pieces will be viable.
If I were developing on one of the NG Amiga Platforms, I would be targeting integration to phones. For example, I would look at having a 'special' window that was a shared screen to a phone, but could be interacted with on the desktop. Currently, the phones have horrible integration to the desktop. Yes, even the iPhone. Maybe especially the iPhone.
Either screen sharing between the desktop and the phone needs to become standard, or the phone needs to become the desktop. Either way, the future will still have full size keyboards, and full sized monitors.