If you have an old Pentium4 pc with even 512 megs ram and an agp graphics card you have an amazing Amiga for Dpaint. Brilliance, and such. You'll easily match 040 speeds. If you have a modern machine even better.
I do Dpaint Pixel art on my Macbook with a Wacom Tablet using Amiga Forever. Stunning.
If you're using an real Amiga DCTV is a great addition as it give you 24 bit animations using ECS chipset bandwith.
For those that have a CS060 or PPC and DCTV you can do some amazing stuff.
Lierbag on these forums does some Amazing stuff using an A1200, scala, 030/50 256 megs and scsi drives. Really shows what the amiga was capable of.