Of course. KDE/Gnome, everything. However, you should first check if linux supports the mediator (I'm not sure if it does).
Unfortunately, there is currently not a single distribution that supports the Mediator.
If I remember correctly, Adam Kowalzcyk (ACK, the PV-guy) was working on it, but dropped it for unknown reasons.
Does anybody know what happened to that project (no, I am not referring to the Powervixxen)?
