It's a bit of an odd jump for MS, I think they're a bit uncertain about how CPU development will go in the future
Microsoft has supported multiple ISA editions via Windows NT 4.0 and Windows CE. There's nothing new here except that MS now has .NET to tie their products together. Their first non-X86 console adventure was with Sega’s Dreamcast (SH4).
AT&T's WebTV was MS's next adventure.
They probably will run out CPU ISAs before they give up…