Hmmm, harware wise... Probably in 1996... When I was playing a real time strategy game (either knights and merchents or command and conqure or something) on my friend's PC... Actually one that had been thrown away by a local college... And I was wondering how I would program something similar on my A1200 and realizing that the Amiga harware offered no advantage at all... In fact it would cause more problems than help me...
I think Win2000 was when the Wintel OS started to piss all over AmigaOS...