Assuming the drive can operate in single-ended mode, it should work (as you say, a lot of adapters though!). You can get 50>80 pin adapters, which would cut down the adapter chain a bit at least.
My experience with 68>80 pin adapters was not good though, poor contact with the 80-pin SCA connection of the hard drive - the hard drive kept dropping out. Cheapo adapters!
There's usually a "force single-ended mode" jumper (usually marked SE), I'd recommend you set that. And, of course, you'll have to set the scsi ID in the 0-7 range, as scsi-2 only has 3 ID bits (0-7).