Let's say you have a game called "Benefactor", for which the name of the CD is "BENEF1". You could do the CD so, that in the root there's a games drawer, which contains "Benefactor" drawer (named after the game, but doesn't have to be). By checking the startup-sequence, let's say it starts "benefactor.bin" from the root of the CD. You want to have the games on a CD called "MyGameCollection".
What you probably would want to do to start the game is:
assign BENEF1: MyGameCollection:games/Benefactor (this makes a (sort of) "virtual drive" that points to the directory where the game files are. If game looks for data files by disc name, they should be found now)
BENEF1: (this changes directory to where the "virtual drive" points to. Works with or without cd)
benefactor.bin
Note: all filenames are just made up, check your discs for what they actually are :-)
Actually I wonder how it would be possible to execute the game-specific startup-sequence directly, so that it will use the assign as root instead of the disc root?
Also, to make any disc bootable with CD32, you need to include CD32 (or CDTV) trademark file, iirc, they're available on amiga developer cd.