But, I have heard a rumour that if you initially mount a drive sideways, run it for a period of time, and then mount it flat (horizontal), the drive wont like it. I have no further info than this.
There may be something in that. For nearly 10 years I didnt use computer cases at all and harddrives where just placed wherever they fit neatly and saftely (at any angle, not always 90 degree angles) on or near my testboards that I sat my mobos on. From time to time things would get moved a little for one reason or another. On occasion a computer might have probs detecting its harddrive and it'd nearly always get resolved by simply moving the drive on a different angle. Im not saying that rumor is definately accurate, but in hindsight there might be something to it. I guess the idea is that with time as the platters get worn in having it operate at a different angle could disturb things, sort of akin to an ass mark in a seat :-)