I've tried amithlon on a few laptops but the video driver (given that laptops have their own unique schemes vs. desktops) usually prevents it from working. AmigaForever (the commercial version of WinUAE) has worked great for me in the past, though.
I guess the key is finding the applications you always use that don't depend on the actual amiga hardware. For instance, Scala, great as it is, doesn't work on AF, UAE, etc. because it REQUIRES the custom hardware. I've tried even MM300 from a CU Amiga version that doesn't have a dongle and this is still the case.
On the other hand, Cinema4D, TVPaint, etc. all work pretty good. DPaint = no, but PPaint = yes, etc.
The other thing I've noticed in using Paint programs generally however, is that sometimes there's an issue with mouse speed or 'delay' in painting the lines vs. your movement of the mouse, which effectively prevents you from using it - so you have to tweak the Input settings sometimes.....
kevin orme
amiga university
www.amigau.com