Big box:
Dump Zorro, PCI only. 5 slots minimum. If it's very low additional cost include 1 or 2 Zorro slots.
SCSI was somewhat expensive, make it optional. EIDE (MW-DMA!) as standard.
Separate CPU & RAM card, no RAM on mainboard. Memory map allows up to 1 GB of RAM on the CPU board.
Move graphics chipset to PCI/Zorro card to make it optional later on.