Well, even the ancient Greeks have pondered on this and more than 2k years later we're no wiser. From a pratical POV, where's the difference? There's most probably NO way to find out what's REALLY going on in this huge and strangely mysterious universe - so we should stick to the things we can understand and bear the rest with humor.
"There is a theory which states that if ever anyone discovers exactly what the Universe is for and why it is here, it will instantly disappear and be replaced by something even more bizarre and inexplicable.
There is another theory which states that this has already happened." (Douglas Adams, of course)
I'm dead sure that when the LHC proves parts of the string theory, some new insights will show that there's still something missing and we're not there yet after all. I don't expect this to change ever...