With the frames in raw format, you could end up with 0% CPU load: let the copper handle all the page flipping (rather lengthy list, but with only a few frames to play).
But: if you have no fast RAM and use HAM (6 planes) you end up with 50% less bandwidth during bitplane DMA. Depending on overscan width, you'd get 25-45% speed penalty for the CPU.
In addition (with fast RAM), you would probably store the ANIM data in fast and decompress directly from fast to chip, so you could use the remaining 55-75% of chipram speed to fill the frames; with few enough bytes to change you could just about get away with full 60 fps.
The Atari STs could only do 16 colors, and with only 4 bitplanes you'd have no speed penalty on the Amiga, so 60 fps would be a piece of cake (with or without fast RAM).