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Wikipedia:Floppy Disk - it's not 100.00% safe to use (previously formatted) HD disks for DD, but it's
very safe (>99.9%). I've been mixing them for years (PC/A3k <-> A500) and the error rate in HD/DD disks wasn't noticably higher than with real DD.
Note that the only difference comes from the formatting done to them, the actual media has always been the very same since the early 90's.
I don't trust a floppy disk further than I can spit it anyway - Murphy states that it's the most important disk that dies next.