It's starting to get unreadable for humans, too. ;-)
Another good way is to make a picture with the letters in it. Use different fonts and capitalization, so it'll be too much work to harvest. If you save it as as JPEG with high compression (low quality option) it's nearly impossible to OCR. :lol:
IMHO it shouldn't be neccessary to filter for spam (chance of false positives and negatives) but instead block based on destination by the ISP. Our mail server uses various external SPAMBL, it's own black list (IP and host name pattern) and dial up detection (via host name) with extremely high success. With numerous 'burned' addresses we only get ~1-2% spam, and that only because the server's pattern matching capabilities are not (yet) good enough.
False positives (rare) are denied right away and the sender gets notified in nearly no time. Since we don't bounce, there are no overflowing outbound queues with invalid senders. :-)