I'm not sure any half modern drive has issues anymore but mine is still set to the value llwath mentions :-)
Exactly. It doesn't hurt anything to change this setting, and it can save you from severe data corruption, if your drive happens to be one of the ones affected by this problem.
I was an early A1200 owner, and had a (high-end at that time) Quantum 2.5" drive in it... It was not a fun combination until my local dealer got a memo from C= on what needed to be set to fix the problem! (I had tried 2 different A1200s from the store, and two different HDs, and both with and without the GVP accelerator...) And most every filesystem available at the time... Lotsa AmigaDOS 3.0 installing experience. This is one setting that caused me enough pain that I'll never forget it. ;-)