All hard drive manufacturers are going to start shiping their hard drives with 4K sectors, and not 512b sectors.
http://www.reghardware.co.uk/2010/03/10/wd_targets_windows_xp_4k/
Does anyone know if Amiga OS (classic and 4.x) will be able to handle this at all, and if not natively, can the OS be patched?
It looks like most of the drives will have a jumper for a 512-byte compatibility mode. This mode may not offer the full performance benefits, but then again, the drive is so much faster than the Amiga interface, I'd be highly surprised if there would be any performance hit by enabling it. So just put the jumper on, the drive presents its logical geometry as 512-byte, problem solved. (Well, other than how you'd recognize 2TB of storage...)