I'd guess you have two problems, Stimp....
1) The CD-ROM sounds dead, to me. Chattery noises are usually a good sign it's time for it to visit the bit-bucket in the sky. They don't make 'em like they used to.
2) Is a bit more complex. I'm going to guess that your 4xEIDE is slightly damaged or misconfigured. It's working in a base IDE mode, but when you have to go to a DMA access, it's having problems. (Hence it works with the base driver, but not the 4xeide.device) Are you sure all your cabling is good? That can also cause intermittent problems at faster IDE modes.
I have a PC motherboard with an on-board Promise UATA100 controller that is half-fried, though. Works fine in base IDE mode, but hook an ultra-ATA cable and drive up, and faster than you can ask "What the hell happened" the drive you just connected is corrupted. You may have to just be careful to keep your IDE interface in a compatability mode...
:-(
Any other guesses/theories? Anyone?