Well I tried the 20G, 40G, and 200G in a 4000D.
200G: will not even try to boot
40G: will boot but doesn't show up in HDToolBox
20G is funny. It will boot and I can see it in HDToolBox but it takes a long time to open the toolbox. Hangs on device 0 or 1. When it finally comes up I can repartition the drive and of course I need to reboot. After the reboot the disk does not show up on the desktop.