Third mouse button can be very useful if you want to clear your RAM DISK: fast. Map it to reset the machine every time you press the button and it will clear the memory as well.
Just be careful to not press the middle button when you have unsaved work.
I usually don't agree with Franko on most issues, but I have to agree that using a click of the MMB to reset your Amiga for the purpose of clearing the RAM disk has got to be one of the strangest uses I have ever read about, compared to the many other uses of the MMB listed by others in this thread.