The worst thing I have done with my Amiga(s) is not use them enough. I have neglected them for too long in the past, but I am trying to make up for that over the last two years.
Other than that, the worst thing I have done is to break, or bend a couple pins when removing peripherals to work on something.
And lastly, I am guilty of buying more Amiga gear than I could possibly use, but I have made up for that by teaching some of the neighborhood kids how computers work with many of my Amigas set up.