MoTrucker. Yes I use my XBOX controller on the PC to. Works great with Joy2Key and other related programs. One of my favorite things is to play through those old FPS classics such as Dark Forces 2: Jedi Knight with a dual analog controller. It makes it somewhat hard again.

And yes, what Cammy and Tenacious are talking about is what I'd heard about. As for three button support you can map one of your buttons to UP on the controller, thus allowing you to also use a button to jump in games like Giana Sisters.
Tenacious: There are a TON of games that support CD32 Games. I've been playing through them as of late. First off you have just about Every CD32 title out there. They all pretty much require that you use more than one button, though for what ever reason Myth seems to require that I still use the freaking arrow keys and space bar to change weapons. What a crock of shit, I must say!
Also Nemac IV, Fears, I think Breathless, and maybe Gloom support it. ADOOM can support all CD32 buttons I think, though you'll want to have a 50Mhz 060 or faster to enjoy that at full screen as turning on Joypad support slows it down a tad.
There are many. And it is only a shame that the PSX adaptor I got wasn't mass produced. It is really one of those pieces of hardware that no Amiga game should live without. Ironically the guy who made it for me has made his Youtube account Private, so I can't even link you to the videos showing it in action.