It depends on what you want to do...
I wouldn't consider programs like ImageFX, ArtEffects (or even Photogenics!) as paint programs per se. So I'd have to go with TV-Paint (especially if you can get a compatible tablet).
TV-Paint is superior to all other Amiga grpahics apps I've tried when it comes to speed and pixel control.
Perhaps you should consider a combo: TV-Paint and a complementary image processing app (I'd recommend ImageFX any time of the day).
