I've always thought it's better to suck up dust than to blow it
elsewhere with a can of air.
I like to use a vacuum cleaner with the bristle attatchment, taking
care to keep it regularly earthed to avoid static damage.
Then to keep the dust away, in your case I would say using a Dyson
HEPA filter fitted to the inside of the PSU fan would prevent any more
being sucked in.
Modern PCs have rubber insulation around the removeable parts to
insulate against noise and dust, they also have filters over inlets.
Do the more technical people thing vacuum cleaners hoses are too
dangerous with regards to static?