Syquest EZ135 drives and Amigas...

[motrucker]

I used to use one with my old X-A1200. You just have to format the cartridge like any other hard drive. I don't remember doing anything more - The Amiga found all of the needed setting for formatting it.
Be careful what you name the cartridges, if you want to use more than one at a sitting.
I used this with an A1200, and Squirrel SCSI interface. Worked great for years.

[motrucker]

There was a huge problem with the media for a while. It's easy to tell the good from the bad however. They made a el-cheapo cart. without a metal hub (just plastic). The better ones have metal hubs - these can be trusted.
I used to use the Squirrel version of HDToolbox, but I can't imagine why that would make a difference.
So, check your cartridge and see what you have....