I use a USB mouse with a PS2 adaptor, which accentially means I`m using a PS2 mouse. I have full wheel support and its very good. The Eyetech Punchinello mk3 is damn good. Be sure to get a Logitech mouse though as they are the best supported by the hardware. Yes some others may work, but I get the impression they are aimed mainly at Logitech`s standards. I used a Logitech optical mouse. Damn damn good!