ImageFX - I've been using it since 1.6 or whatever was given away on one of those UK magazine coverdisks and still like it. Can't bother to learn Photoshop or Gimp for the few things I use it for. The latest 4.5 has all the features I need.
Bars&Pipes for midi. It's fast, simple and no latency. I'm used to it since ages.
