Worst two things I ever did to my Amiga's:
I once broke my A570 by using the on/off switch while the Amiga was on. Broke my heart and the darned things where not obtainable anymore either so my nifty CD Rom drive was gone :-(
I also gave away my original A500 some years later. I'm still regretting it. The replacement I eventually got was not quite the same model and somehow misses something as a result. Silly thing, nostalgia.