50,000 units might be a big stretch!
1,000 ... yeah, I think you could shift them over time - enough to be profitable, especially if someone developed a C64 core, an Atari 8-bit core and an Atari ST core, and it came with some licensed games. I guess you could even get a Megadrive core implemented... but you'd never get any games.
But for orders being taken via web forums? 100 assembled boards, maybe 200. But better to take a risk with the V1.1, whereas you would probably want the V2 design complete for any larger run.
However a company might decide to fabricate the Verilog into a proper chip with a 68k core, and create a proper product out of it. FPGAs aren't cheap, but a <20mm^2 chip is, made in suitable quantities. Again, let's get V2 designed first!