There's something I dislike about emulation in the manner of UAE or Fellow ... probably the host OS getting in the way.
It seems that the CPU emulation is very good, and running a virtual 500MHz 68k on a modern system is great, and for Workbench mode and CPU speed aware 3D games it is great. However the chipset emulation, although good, isn't the same as the real hardware. This makes game emulation and demos (in particular) not feel right.
Hence MiniMig for classic Amiga hardware replication. Whilst I don't think AGA will occur (entirely) on the current hardware design, it could occur on a later hardware design in a year or so. No harm in owning both! MiniMig will be the way to play old games and demos directly on the hardware.
As for the OS side of things, making it run on a standard PC seems the sensible option to me. At least make it run on old PowerPC Macs in the current iteration, and leave the x86-64 version for the next major release.