Is the crashing entirely random? Or does it happen in particular applications (such as all MUI apps...)?
How have you set the USB mouse up in Poseidon? Is it a HID class or bootmouse class device?
I am using Poseidon V2.2, USB cheapo 3 button (configured as HID class mouse), scrollwheel mouse, attached to an Algor USB controller...no problems here. (running MUIWheel 1.4 and FreeWheel 2.1 (I think...not an Amiga atm...)...anyway the lastest version of these programs...)
Do you have the latest driver for the Spider USB card installed? Can you revert back to an older version, if you do have the latest version, and see if the problems persist?
Are you running any other hardware/software hacks that may clash/interfere with Poseidon? Can you catch any of the crashes with snoopdos or any other snooping software? If so, what does the log say?