For picture creation... BeOS/Zeta - Refraction is a very nice smooth package in the style of Photogenics
For Multimedia playback I stick with BeOS/Zeta, But I would say that its creation tools suck big time, even the Amiga has a greater range of pro tools. That said though, it does offer some pretty fine development tools in the form of CodeLiege as well as other tools.
If you're going to go into music/video creation a lot I'd say go with Windows 2000pro or get a mac as they are really the only choices that are cost effective. And games... Sorry folks but I'd have to say Windows if you're after the latest and greatest....
Ease of use... BeOS/Zeta simply the slickest OS on X86 bar none.