When I boot WB 2.04 on my A2000 (6Mb RAM), df1 is available for reading, writing, and formatting. However, when I boot up Faery Tale Adventure, the drive is not recognized. I have to do everything via df0. I know an A500 will recognize a df1 as I've used an A500 before with this game.
A lot of Amiga games didn't support a second drive because the presence of one ate into chip ram.