yes, antivirus usually makes computer slower, but NOT IF YOU DISABLE 'real time' scan. Install KAV, then prevent it from starting at boot up , and disable two services it creates. everytime you wish to install something scan it manually (updating the signatures first).
IMHO, antispyware isn't essential once you clean your system, you won't need it again if everything is configured right. of course, use EMULE for all er.. needs.. ;-)