Many years ago when I was first working on making an AGA version of Chaos: Wizard War II, I was going to make the AGA version run in 1280x512 (SuperHiRes) with 256 colors or HAM8.
I was
shocked to discover that SuperHiRes was all trashed out on my Flicker Fixer display! But it looked awesome on my 1084S! I thought my FlickerFixer was broken!
Then I found out that no known Flicker Fixer supports SuperHiRes.

So I had to scale the game back to 640x512 with 256 colors.