I trialed Ubuntu for a while. Openoffice and Gimp are both very good packages even if they do have a certain freeware feel to them; with little graphical glitches, hit and miss screen redraw and patchy file type compatability.
I used OSX for a while too but purchasing the same software on two different platforms (doubling our costs) meant that our already established Windows machines always got first preference.
When I have to do something in a hurry, I always fall back on Windows and its apps. Years or practice and learning the quirks make using something else while under pressure an unnecessary chore.
This is probably the same reason people have stuck with AOS, other OSes are less familiar and can become unpleasant to use.
I think any Amiga based OS will have a hard time attracting an audience outside the Amiga scene, especially when it comes to serious (non-hobby) use. Even with "killer apps" lined up, maybe you'll get a few hundread "once-were" users coming back but I doubt there'll be a flood of overnight converts.