Setting the PIO too high can cause problems. When I first installed my Flyer4000, I set the PIO too high for my older IDE drive. I would delete the prefs file & reboot. When the prefs window comes up, change nothing & OK it. After booting, open prefs & set for no-split, leave PIO at zero & see if it works. On my new drive, I set the PIO no higher then 4 for reliability.