Worst games without a doubt are those I blame for helping kill the Amiga...
Ultima VI
Wing Commander
Kings Quest 5
Ultima VI was programmed from the ground up on an IBM/Clone development platform and after Origins' abysmal failure with Ultima V (remember the 1 track soundtrack anyone?) they had an opportunity to redeem themselves...this wasn't it...slow as molasses on a 68000 because it uses custom IBM/Clone CPU blitting routines.
Wing Commander was probably the most disgraceful port ever...the 68000 could have handled the blitting for the ships with its eyes closed but instead we had to suffer through brutal CPU driven blitting calculations that brought our 68000s to a standstill...utterly, utterly disgraceful.
Kings Quest 5 could (with my limited Amiga hardware knowledge) have been programmed in Extra Half bright mode which would have allowed for a much more colourful palette of 64 colours as opposed to 32. Can someone explain to me why your main character moving alone over a static bitmap brought the mighty Amiga to its knees...
answer: not only did this terrible port use custom CPU blitting routines that didn't take advantage of the Amiga's hardware it also was built using an interpretive engine which created yet more work for the Amiga...thumbs down to the lazy buggers at Sierra. Should have been more colourful with a ripping soundtrack but alas...it wasn't.
These three games as mentioned in the Amiga downfall thread in the Hardware section are what I blame for many things...utterly disgraceful and abysmal...shame on Origina and Sierra.