The spider might be a little bit faster then the Algor/Highway. At best about double the speed, resulting in about 2 MB/s transferrate maximum (the external USB-drive I have gives about 700kb/s on my Algor).
DMA isnt an issue here, as the Mediator can not DMA into FastRAM, but only into the RAM of the PCI GFX-card, from there it as to betransfered the "traditional" way.
Bottomline: USB on (classic) Amiga isn't appropriate for often used drives let alone the systempartiton at all. Besides you can't boot from the spider.