try a old amiga game and a sample ripper.in winuae you can too rip samples-
you see sample rate is not often larger as 7 khz, because on A500 memory was low and memory need save
also transpose a sample with paula have very ugly sound quality.amiga have a 7 khz filter so it sound not so ugly as when disable the filter.
modern systems as sdlmixer use linear transpose this cost more CPU power but have good sound quality so you can get CD quality sound
so the first thing you can do, when you want play a sdl game on a slow amiga, is switch music and sound off.
Who's talking about the A500? who in their right mind would try running SDL on such a platform? Also, much of the OCS limitations came from lack of storage space, not bus throughput. I quite happily play 14bit multi channel ADPCM music on my A1200/030, and it sounds brilliant. And the machine has plenty of bandwidth for other tasks.
The first thing you want to do if you play a game on Amiga is not use SDL, and use as many amiga hardware tricks as you can. Many Amiga demo's run in HAM modes and have 14bit sound. SDL would not allow this on such a limited platform, and I would it even allow you to reach such a low level? I doubt it.