Lightwave - Still a top 3D package
Cinema 4D - still going strong
Brilliance - A few influenced by this.
Blitz basic - Still going I think.
Dpaint - still being copied to this day (grafx2, pro motion).
Fantavision - Vector animation long before flash.
Soundtracker - Don't know how many trackers came after this, but a lot
Deliplayer - I think you can get Deliplayer on a few platforms, and many use it's players.
DOpus - Still going. and quite a few clones too.
canDO - Visual basic before visual basic
Workbench/intuition
